Target：S5A1

Fields：Steroid hormone biosynthesis;Metabolic pathways

Gene Name：SRD5A1

Protein Name：3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.30) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1)

Human Gene Id：6715

Human Swiss Prot No：P18405

Mouse Swiss Prot No：Q68FF9

Rat Swiss Prot No：P24008

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：S5A1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：28kD

Background： Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008],

Function：catalytic activity:A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.,function:Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.,induction:Its expression is regulated by androgens such as testosterone.,online information:5-alpha reductase entry,similarity:Belongs to the steroid 5-alpha reductase family.,tissue specificity:Liver and prostate (at a low level).,

Subcellular Location：Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Expression：Liver and prostate (at a low level).