Target：S10A7

Fields：IL-17 signaling pathway

Gene Name：S100A7 PSOR1 S100A7C

Protein Name：Protein S100-A7 (Psoriasin) (S100 calcium-binding protein A7)

Human Gene Id：6278

Human Swiss Prot No：P31151

Immunogen：Synthesized peptide derived from human protein . at AA range: 40-120

Specificity：S10A7 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：11kD

Background：S100 calcium binding protein A7(S100A7) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014],

Function：mass spectrometry: PubMed:8526920,similarity:Belongs to the S-101 family.,similarity:Contains 2 EF-hand domains.,subcellular location:Secreted by a non-classical secretory pathway.,subunit:Interacts with RANBP9.,tissue specificity:Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.,

Subcellular Location：Cytoplasm . Secreted . Secreted by a non-classical secretory pathway.

Expression：Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.