Target：AIM2

Fields：NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway

Gene Name：AIM2

Protein Name：Interferon-inducible protein AIM2

Human Gene Id：9447

Human Swiss Prot No：O14862

Mouse Swiss Prot No：Q91VJ1

Immunogen：The antiserum was produced against synthesized peptide derived from human AIM2. AA range:51-100

Specificity：AIM2 Polyclonal Antibody detects endogenous levels of AIM2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AIM2;Interferon-inducible protein AIM2;Absent in melanoma 2

Observed Band(KD)：39kD

Background： AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008],

Function：disease:Defects in AIM2 may be a cause of microsatellite unstable colon cancers.,function:Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.,induction:By interferon gamma.,similarity:Belongs to the HIN-200 family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 HIN-200 domain.,subunit:Homodimer.,tissue specificity:Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.,

Subcellular Location：Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles.

Expression：Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.