Target：HEI10

Gene Name：CCNB1IP1

Protein Name：E3 ubiquitin-protein ligase CCNB1IP1

Human Gene Id：57820

Human Swiss Prot No：Q9NPC3

Immunogen：The antiserum was produced against synthesized peptide derived from human CCNB1IP1. AA range:201-250

Specificity：HEI10 Polyclonal Antibody detects endogenous levels of HEI10 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CCNB1IP1;C14orf18;HEI10;E3 ubiquitin-protein ligase CCNB1IP1;Cyclin-B1-interacting protein 1;Human enhancer of invasion 10

Observed Band(KD)：32kD

Background： HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004],

Function：function:E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated by CDC2 on serine or threonine residues (in vitro).,PTM:Ubiquitinated; autoubiquitinated.,similarity:Contains 1 RING-type zinc finger.,subcellular location:May associate with segregating chromosomes during metaphase and anaphase.,subunit:Binds CCNB1 and UBE2L3.,tissue specificity:Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.,

Subcellular Location：Nucleus. Chromosome. Associates to the synaptonemal complex.

Expression：Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.