Target：AGTR2

Fields：Neuroactive ligand-receptor interaction;Adrenergic signaling in cardiomyocytes;Renin-angiotensin system

Gene Name：AGTR2

Protein Name：Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2)

Human Gene Id：186

Human Swiss Prot No：P50052

Mouse Swiss Prot No：P35374

Rat Swiss Prot No：P35351

Immunogen：Synthesized peptide derived from human protein . at AA range: 30-110

Specificity：AGTR2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：39kD

Background： The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010],

Function：function:Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with MTUS1.,tissue specificity:In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.