Target：HBXIP

Fields：mTOR signaling pathway

Gene Name：HBXIP XIP

Protein Name：Hepatitis B virus X-interacting protein (HBV X-interacting protein) (HBX-interacting protein)

Human Gene Id：10542

Human Swiss Prot No：O43504

Immunogen：Synthesized peptide derived from part region of human protein AA range: 1-50

Specificity：HBXIP Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：10kD

Background： This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008],

Function：function:When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.,miscellaneous:Suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the HBXIP family.,subunit:Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.,tissue specificity:Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and no

Subcellular Location：Lysosome . Cytoplasm, cytosol .

Expression：Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.