Target：AGO3

Gene Name：EIF2C3 AGO3

Protein Name：Protein argonaute-3 (Argonaute3) (hAgo3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)

Human Gene Id：192669

Human Swiss Prot No：Q9H9G7

Mouse Swiss Prot No：Q8CJF9

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：AGO3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：94kD

Background： This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],

Function：function:Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.,similarity:Belongs to the argonaute family. Ago subfamily.,similarity:Contains 1 PAZ domain.,similarity:Contains 1 Piwi domain.,subunit:Interacts with EIF4B, IMP8, PRMT5 and TNRC6B.,

Subcellular Location：Cytoplasm, P-body .

Expression： Placenta,Testis,