Target：HAP1

Fields：GABAergic synapse;Amyotrophic lateral sclerosis;Huntington disease;Pathways of neurodegeneration - multiple diseases

Gene Name：HAP1 HAP2 HLP1

Protein Name：Huntingtin-associated protein 1 (HAP-1) (Neuroan 1)

Human Gene Id：9001

Human Swiss Prot No：P54257

Mouse Swiss Prot No：O35668

Rat Swiss Prot No：P54256

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：HAP1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：73kD

Background： Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

Function：alternative products:Additional isoforms seem to exist,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat.,similarity:Contains 1 HAP1 N-terminal domain.,tissue specificity:Predominantly expressed in brain. Selectively expressed in neurons.,

Subcellular Location：Cytoplasm . Cell projection, axon . Cell junction, synapse, presynapse . Cytoplasm, cytoskeleton . Cell projection, dendritic spine . Cell projection, dendrite . Lysosome . Endoplasmic reticulum . Mitochondrion . Nucleus . Cytoplasmic vesicle, autophagosome . Early endosome . Cell projection, growth cone . Cell projection, neuron projection . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Localizes to large nonmembrane-bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs). Localization to neuronal processes and neurite tips is decreased by YWHAZ. In the nucleus localizes to nuclear rods. .

Expression：Predominantly expressed in brain. Selectively expressed in neurons.