Target：ACO2

Fields：Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Carbon metabolism;2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids

Gene Name：ACO2

Protein Name：ACO2

Human Gene Id：50

Human Swiss Prot No：Q99798

Mouse Gene Id：11429

Mouse Swiss Prot No：Q99KI0

Immunogen：Synthesized peptide derived from human ACO2. at AA range: 421-470

Specificity：ACO2 Polyclonal Antibody detects endogenous levels of ACO2

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000.Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)

Observed Band(KD)：90kD

Background： The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Citrate = isocitrate.,cofactor:Binds 1 4Fe-4S cluster per subunit. Binding of a 3Fe-4S cluster leads to an inactive enzyme.,online information:Aconitase entry,pathway:Carbohydrate metabolism; tricarboxylic acid cycle.,similarity:Belongs to the aconitase/IPM isomerase family.,subunit:Monomer.,

Subcellular Location：Mitochondrion .

Expression： Brain,Cajal-Retzius cell,Fetal brain cortex,Skeletal muscle,Uterus,