Target：ACINU

Fields：Nucleocytoplasmic transport;mRNA surveillance pathway;Spliceosome

Gene Name：ACIN1 ACINUS KIAA0670

Protein Name：Apoptotic chromatin condensation inducer in the nucleus (Acinus)

Human Gene Id：22985

Human Swiss Prot No：Q9UKV3

Mouse Swiss Prot No：Q9JIX8

Immunogen：Synthesized peptide derived from human protein . at AA range: 1120-1200

Specificity：ACINU Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：147kD

Background： Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],

Function：function:Induces apoptotic chromatin condensation after activation by CASP3.,PTM:Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.,similarity:Contains 1 SAP domain.,subunit:Interacts with API5.,tissue specificity:Ubiquitous.,

Subcellular Location：Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.

Expression：Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.