Target：RXRγ

Fields：PPAR signaling pathway;Th17 cell differentiation;Thyroid hormone signaling pathway;Adipocytokine signaling pathway;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;Transcriptional misregulation in cancer;Chemical carcinogenesis - receptor activation;Thyroid cancer;Small cell lung cancer;Non-small cell lung cancer;Gastric cancer;Lipid and atherosclerosis

Gene Name：RXRG

Protein Name：Retinoic acid receptor RXR-gamma

Human Gene Id：6258

Human Swiss Prot No：P48443

Mouse Gene Id：20183

Mouse Swiss Prot No：P28705

Immunogen：The antiserum was produced against synthesized peptide derived from human Retinoid X Receptor gamma. AA range:171-220

Specificity：RXRγ Polyclonal Antibody detects endogenous levels of RXRγ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RXRG;NR2B3;Retinoic acid receptor RXR-gamma;Nuclear receptor subfamily 2 group B member 3;Retinoid X receptor gamma

Observed Band(KD)：50kD

Background：retinoid X receptor gamma(RXRG) Homo sapiens This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010],

Function：caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,

Subcellular Location：Nucleus . Cytoplasm .

Expression：Expressed in aortic endothelial cells (at protein level).