Target：Granzyme H

Gene Name：GZMH

Protein Name：Granzyme H

Human Gene Id：2999

Human Swiss Prot No：P20718

Immunogen：The antiserum was produced against synthesized peptide derived from human GRAH. AA range:51-100

Specificity：Granzyme H Polyclonal Antibody detects endogenous levels of Granzyme H protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GZMH;CGL2;CTSGL2;Granzyme H;CCP-X;Cathepsin G-like 2;CTSGL2;Cytotoxic T-lymphocyte proteinase;Cytotoxic serine protease C;CSP-C

Observed Band(KD)：23kD

Background： This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015],

Function：function:This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Cytoplasmic granules of cytolytic T-lymphocytes.,

Subcellular Location：Cytolytic granule .

Expression：Constitutively expressed in NK cells.