Target：Granzyme A

Fields：Neuroactive ligand-receptor interaction

Gene Name：GZMA

Protein Name：Granzyme A

Human Gene Id：3001

Human Swiss Prot No：P12544

Mouse Swiss Prot No：P11032

Immunogen：The antiserum was produced against synthesized peptide derived from human GRAA. AA range:61-110

Specificity：Granzyme A Polyclonal Antibody detects endogenous levels of Granzyme A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GZMA;CTLA3;HFSP;Granzyme A;CTL tryptase;Cytotoxic T-lymphocyte proteinase 1;Fragmentin-1;Granzyme-1;Hanukkah factor;H factor;HF

Molecular Weight(Da)：29kD

Background： Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- -Phe-|-Xaa- in small molecule substrates.,function:This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. May be involved in apoptosis.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subunit:Homodimer; disulfide-linked.,

Subcellular Location：[Isoform alpha]: Secreted . Cytoplasmic granule . Delivered into the target cell by perforin. .

Expression： Blood,Liver,T-cell,