Target：GPX1

Fields：Glutathione metabolism;Arachidonic acid metabolism;Metabolic pathways;Thyroid hormone synthesis;Amyotrophic lateral sclerosis;Huntington disease;Pathways of neurodegeneration - multiple diseases

Gene Name：GPX1

Protein Name：Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase)

Human Gene Id：2876

Human Swiss Prot No：P07203

Mouse Swiss Prot No：P11352

Rat Swiss Prot No：P04041

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：GPX1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：22kD

Background： The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA cod

Function：catalytic activity:2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.,function:Protects the hemoglobin in erythrocytes from oxidative breakdown.,online information:Glutathione peroxidase entry,similarity:Belongs to the glutathione peroxidase family.,subunit:Homotetramer.,

Subcellular Location：Cytoplasm.

Expression：Expressed in platelets (at protein level).