Target：GPR40

Fields：Insulin secretion

Gene Name：FFAR1

Protein Name：Free fatty acid receptor 1

Human Gene Id：2864

Human Swiss Prot No：O14842

Mouse Swiss Prot No：Q76JU9

Immunogen：The antiserum was produced against synthesized peptide derived from human FFAR1. AA range:185-234

Specificity：GPR40 Polyclonal Antibody detects endogenous levels of GPR40 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FFAR1;GPR40;Free fatty acid receptor 1;G-protein coupled receptor 40

Observed Band(KD)：26kD

Background： This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009],

Function：function:Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly in pancreatic beta cells.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Detected in brain and pancreas. Detected in pancreatic beta cells.