Target：GPR3

Gene Name：GPR3 ACCA

Protein Name：G-protein coupled receptor 3 (ACCA orphan receptor)

Human Gene Id：2827

Human Swiss Prot No：P46089

Mouse Swiss Prot No：P35413

Rat Swiss Prot No：Q8K1Q3

Immunogen：Synthesized peptide derived from human protein . at AA range: 260-340

Specificity：GPR3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：36kD

Background： This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012],

Function：function:Orphan receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.