Target：Oncogene TIM

Gene Name：ARHGEF5

Protein Name：Rho guanine nucleotide exchange factor 5

Human Gene Id：7984

Human Swiss Prot No：Q12774

Immunogen：The antiserum was produced against synthesized peptide derived from human ARHGEF5. AA range:1280-1330

Specificity：Oncogene TIM Polyclonal Antibody detects endogenous levels of Oncogene TIM protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ARHGEF5;TIM;Rho guanine nucleotide exchange factor 5;Ephexin-3;Guanine nucleotide regulatory protein TIM;Oncogene TIM;Transforming immortalized mammary oncogene;p60 TIM

Observed Band(KD)：60kD

Background： Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008],

Function：similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Mainly expressed in kidney, liver, pancreas, lung and placenta.,

Subcellular Location：Cytoplasm . Nucleus . Cell projection, podosome .

Expression：Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624). Expressed at low levels in lung and heart (PubMed:14662653).