Target：HLA-DOα

Fields：Phagosome;Cell adhesion molecules;Antigen processing and presentation;Hematopoietic cell lineage;Th1 and Th2 cell differentiation;Th17 cell differentiation;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;Human T-cell leukemia virus 1 infection;Herpes simplex virus 1 infection;Epstein-Barr virus infection;Asthma;Autoimmune thyroid disease;Inflammatory bowel disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis

Gene Name：HLA-DOA

Protein Name：HLA class II histocompatibility antigen DO alpha chain

Human Gene Id：3111

Human Swiss Prot No：P06340

Immunogen：The antiserum was produced against synthesized peptide derived from human HLA-DOA. AA range:71-120

Specificity：HLA-DOα Polyclonal Antibody detects endogenous levels of HLA-DOα protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HLA-DOA;HLA-DNA;HLA-DZA;HLA class II histocompatibility antigen; DO alpha chain;MHC DN-alpha;MHC DZ alpha;MHC class II antigen DOA

Observed Band(KD)：34kD

Background： HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008],

Function：function:Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule.,polymorphism:The only allele of DOA known is DOA*0101 which is shown here.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain (DOA) and a beta chain (DOB).,

Subcellular Location：Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Expression： Lymph,