Target：UDP-GlcDH

Fields：Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of cofactors;Biosynthesis of nucleotide sugars

Gene Name：UGDH

Protein Name：UDP-glucose 6-dehydrogenase

Human Gene Id：7358

Human Swiss Prot No：O60701

Mouse Gene Id：22235

Mouse Swiss Prot No：O70475

Rat Gene Id：83472

Rat Swiss Prot No：O70199

Immunogen：The antiserum was produced against synthesized peptide derived from human UGDH. AA range:391-440

Specificity：UDP-GlcDH Polyclonal Antibody detects endogenous levels of UDP-GlcDH protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：UGDH;UDP-glucose 6-dehydrogenase;UDP-Glc dehydrogenase;UDP-GlcDH;UDPGDH

Observed Band(KD)：55kD

Background： The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

Function：catalytic activity:UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.,function:Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.,pathway:Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1.,similarity:Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.,subunit:Homohexamer.,

Subcellular Location：nucleus,nucleoplasm,cytosol,extracellular exosome,

Expression：Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970).