Target：Latrophilin-2

Gene Name：LPHN2

Protein Name：Latrophilin-2

Human Gene Id：23266

Human Swiss Prot No：O95490

Mouse Swiss Prot No：Q8JZZ7

Rat Gene Id：171447

Rat Swiss Prot No：O88923

Immunogen：The antiserum was produced against synthesized peptide derived from human LPHN2. AA range:551-600

Specificity：Latrophilin-2 Polyclonal Antibody detects endogenous levels of Latrophilin-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LPHN2;KIAA0786;LEC1;LPHH1;Latrophilin-2;Calcium-independent alpha-latrotoxin receptor 2;CIRL-2;Latrophilin homolog 1;Lectomedin-1

Molecular Weight(Da)：163kD

Background： This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Function：function:Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 olfactomedin-like domain.,similarity:Contains 1 SUEL-type lectin domain.,subunit:Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85).,tissue specificity:Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly r

Subcellular Location：Membrane ; Multi-pass membrane protein .

Expression：Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.