Target：LBP

Fields：NF-kappa B signaling pathway;Toll-like receptor signaling pathway;Alcoholic liver disease;Tuberculosis;Lipid and atherosclerosis

Gene Name：LBP

Protein Name：Lipopolysaccharide-binding protein

Human Gene Id：3929

Human Swiss Prot No：P18428

Mouse Gene Id：16803

Mouse Swiss Prot No：Q61805

Rat Swiss Prot No：Q63313

Immunogen：The antiserum was produced against synthesized peptide derived from human LBP. AA range:221-270

Specificity：LBP Polyclonal Antibody detects endogenous levels of LBP protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LBP;Lipopolysaccharide-binding protein;LBP

Observed Band(KD)：53kD

Background：lipopolysaccharide binding protein(LBP) Homo sapiens The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012],

Function：function:Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex seems to interact with the CD14 receptor.,similarity:Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.,

Subcellular Location：Secreted . Cytoplasmic granule membrane . Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. .

Expression：Detected in blood serum (at protein level).