Target：LPPR4
Gene Name：LPPR4 KIAA0455 PRG1
Protein Name：Lipid phosphate phosphatase-related protein type 4 (EC 3.1.3.4) (Brain-specific phosphatidic acid phosphatase-like protein 1) (Plasticity-related gene 1 protein) (PRG-1)
Human Gene Id：9890
Human Swiss Prot No：Q7Z2D5
Mouse Swiss Prot No：Q7TME0
Rat Swiss Prot No：Q7TMB7
Immunogen：Synthesized peptide derived from part region of human protein.AA55-80
Specificity：LPPR4 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：83kD
Background： The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],
Function：catalytic activity:A 3-sn-phosphatidate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.,function:Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.,similarity:Belongs to the PA-phosphatase related phosphoesterase family.,tissue specificity:Specifically expressed in neurons.,
Subcellular Location：Cell junction, synapse, postsynaptic density membrane ; Multi-pass membrane protein .
Expression：Expressed by glutamatergic neurons (at protein level).
