Target：LRBA

Gene Name：LRBA BGL CDC4L LBA

Protein Name：Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)

Human Gene Id：987

Human Swiss Prot No：P50851

Mouse Swiss Prot No：Q9ESE1

Immunogen：Synthesized peptide derived from human protein . at AA range: 1970-2050

Specificity：LRBA Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:50-300. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：314kD

Background： The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],

Function：caution:Was originally (PubMed:1505956) said to be similar to yeast CDC4, but that similarity is very limited.,induction:By lipopolysaccharide (LPS).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 BEACH domain.,similarity:Contains 6 WD repeats.,

Subcellular Location：Cell membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein .

Expression：Ubiquitous.