Target：LRP12

Gene Name：LRP12 ST7

Protein Name：Low-density lipoprotein receptor-related protein 12 (LRP-12) (Suppressor of tumorigenicity 7 protein)

Human Gene Id：29967

Human Swiss Prot No：Q9Y561

Mouse Swiss Prot No：Q8BUJ9

Immunogen：Synthesized peptide derived from human protein . at AA range: 90-170

Specificity：LRP12 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：94kD

Background： This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],

Function：function:Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.,similarity:Belongs to the LDLR family.,similarity:Contains 2 CUB domains.,similarity:Contains 5 LDL-receptor class A domains.,subunit:May interact with GNB2L1, MADHIP and ITGB1BP3.,tissue specificity:Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.,

Subcellular Location：Membrane ; Single-pass type I membrane protein . Membrane, coated pit .

Expression：Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.