Target：LRP1B
Gene Name：LRP1B LRPDIT
Protein Name：Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT)
Human Gene Id：53353
Human Swiss Prot No：Q9NZR2
Mouse Swiss Prot No：Q9JI18
Immunogen：Synthesized peptide derived from human protein . at AA range: 200-280
Specificity：LRP1B Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:50-300. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：505kD
Background： This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016],
Function：function:Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.,miscellaneous:The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs.,similarity:Belongs to the LDLR family.,similarity:Contains 14 EGF-like domains.,similarity:Contains 32 LDL-receptor class A domains.,similarity:Contains 36 LDL-receptor class B repeats.,subunit:Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.,tissue specificity:Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.,
Subcellular Location：Membrane ; Single-pass type I membrane protein .
Expression：Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.
