Target：CNG-2

Fields：cAMP signaling pathway;Olfactory transduction

Gene Name：CNGA2

Protein Name：Cyclic nucleotide-gated olfactory channel

Human Gene Id：1260

Human Swiss Prot No：Q16280

Mouse Gene Id：12789

Mouse Swiss Prot No：Q62398

Rat Gene Id：25411

Rat Swiss Prot No：Q00195

Immunogen：The antiserum was produced against synthesized peptide derived from human CNGA2. AA range:391-440

Specificity：CNG-2 Polyclonal Antibody detects endogenous levels of CNG-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CNGA2;CNCA;CNCA1;CNCG2;Cyclic nucleotide-gated olfactory channel;Cyclic nucleotide-gated cation channel 2;Cyclic nucleotide-gated channel alpha-2;CNG channel alpha-2;CNG-2;CNG2

Observed Band(KD)：83kD

Background： The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010],

Function：function:Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.,similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,

Subcellular Location：Membrane; Multi-pass membrane protein.

Expression： Testis,