Target：CNG-1

Fields：cGMP-PKG signaling pathway;cAMP signaling pathway;Phototransduction

Gene Name：CNGA1

Protein Name：cGMP-gated cation channel alpha-1

Human Gene Id：1259

Human Swiss Prot No：P29973

Mouse Gene Id：12788

Mouse Swiss Prot No：P29974

Rat Gene Id：85259

Rat Swiss Prot No：Q62927

Immunogen：The antiserum was produced against synthesized peptide derived from human CNGA1. AA range:401-450

Specificity：CNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CNGA1;CNCG;CNCG1;cGMP-gated cation channel alpha-1;Cyclic nucleotide-gated cation channel 1;Cyclic nucleotide-gated channel alpha-1;CNG channel alpha-1;CNG-1;CNG1;Cyclic nucleotide-gated channel; photoreceptor;Rod photoreceptor cG

Observed Band(KD)：80kD

Background： The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],

Function：caution:It is uncertain whether Met-1 or Met-5 is the initiator.,disease:Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subuni

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Rod cells in the retina.