Target：CMTA1

Gene Name：CAMTA1 KIAA0833 MSTP023

Protein Name：Calmodulin-binding transcription activator 1

Human Gene Id：23261

Human Swiss Prot No：Q9Y6Y1

Mouse Swiss Prot No：A2A891

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CMTA1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：184kD

Background：disease:Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma.,function:Transcriptional activator. May act as a tumor suppressor.,induction:Detected at low levels at interphase and in resting cells. Up-regulated during S-phase and mitosis. Levels decrease at the end of mitosis.,similarity:Belongs to the CAMTA family.,similarity:Contains 1 CG-1 DNA-binding domain.,similarity:Contains 1 IPT/TIG domain.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 IQ domains.,subunit:May interact with calmodulin .,tissue specificity:Detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen, heart and kidney. Detected in neuroblastic-type cultured neuroblastoma cells.,

Function：disease:Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma.,function:Transcriptional activator. May act as a tumor suppressor.,induction:Detected at low levels at interphase and in resting cells. Up-regulated during S-phase and mitosis. Levels decrease at the end of mitosis.,similarity:Belongs to the CAMTA family.,similarity:Contains 1 CG-1 DNA-binding domain.,similarity:Contains 1 IPT/TIG domain.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 IQ domains.,subunit:May interact with calmodulin .,tissue specificity:Detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen, heart and kidney. Detected in neuroblastic-type cultured neuroblastoma cells.,

Subcellular Location：Nucleus . Cytoplasm .

Expression：Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.