Target：CLK1

Fields：Legionellosis

Gene Name：CLK1

Protein Name：Dual specificity protein kinase CLK1

Human Gene Id：1195

Human Swiss Prot No：P49759

Mouse Gene Id：12747

Mouse Swiss Prot No：P22518

Immunogen：The antiserum was produced against synthesized peptide derived from human CLK1. AA range:101-150

Specificity：CLK1 Polyclonal Antibody detects endogenous levels of CLK1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CLK1;CLK;Dual specificity protein kinase CLK1;CDC-like kinase 1

Observed Band(KD)：57kD

Background：CDC like kinase 1(CLK1) Homo sapiens This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.,PTM:Autophosphorylates on all three types of residues.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPIG.,

Subcellular Location：Nucleus.

Expression：Endothelial cells.