Target：CLIP-170
Fields：mTOR signaling pathway
Gene Name：CLIP1
Protein Name：CAP-Gly domain-containing linker protein 1
Human Gene Id：6249
Human Swiss Prot No：P30622
Mouse Gene Id：56430
Mouse Swiss Prot No：Q922J3
Immunogen：The antiserum was produced against synthesized peptide derived from human CLIP1. AA range:1291-1340
Specificity：CLIP-170 Polyclonal Antibody detects endogenous levels of CLIP-170 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CLIP1;CYLN1;RSN;CAP-Gly domain-containing linker protein 1;Cytoplasmic linker protein 1;Cytoplasmic linker protein 170 alpha-2;CLIP-170;Reed-Sternberg intermediate filament-associated protein;Restin
Observed Band(KD)：161kD
Background： The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Function：function:Seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules.,similarity:Contains 2 CAP-Gly domains.,subcellular location:Associated with the cytoskeleton.,tissue specificity:Highly expressed in the Reed-Sternberg cells of Hodgkin's disease.,
Subcellular Location：Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle . Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698). .
Expression：Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.
