Target：MMP-23

Gene Name：MMP23B

Protein Name：Matrix metalloproteinase-23

Human Gene Id：8510

Human Swiss Prot No：O75900

Mouse Gene Id：26561

Mouse Swiss Prot No：O88676

Rat Gene Id：94339

Rat Swiss Prot No：O88272

Immunogen：The antiserum was produced against synthesized peptide derived from human MMP23. AA range:60-109

Specificity：Cleaved-MMP-23 (Y79) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-23 protein resulting from cleavage adjacent to Y79.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MMP23A;MMP21;MMP23B;MMP21;MMP22;Matrix metalloproteinase-23;MMP-23;Femalysin;MIFR-1;Matrix metalloproteinase-21;MMP-21;Matrix metalloproteinase-22;MMP-22

Observed Band(KD)：36kD

Background： This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008],

Function：cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by TIMP2.,function:Protease.,PTM:N-glycosylated.,PTM:Proteolytic cleavage might yield an active form.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subcellular location:A secreted form produced by proteolytic cleavage seems also to exist.,tissue specificity:Predominantly expressed in ovary, testis and prostate.,

Subcellular Location：Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Membrane ; Single-pass type II membrane protein . A secreted form produced by proteolytic cleavage may also exist. .

Expression：Predominantly expressed in ovary, testis and prostate.