Target：GGT4 HC

Fields：Taurine and hypotaurine metabolism;Glutathione metabolism;Metabolic pathways

Gene Name：GGT7

Protein Name：Gamma-glutamyltransferase 7

Human Gene Id：2686

Human Swiss Prot No：Q9UJ14

Mouse Gene Id：207182

Mouse Swiss Prot No：Q99JP7

Rat Gene Id：156275

Rat Swiss Prot No：Q99MZ4

Immunogen：The antiserum was produced against synthesized peptide derived from human Gamma-glutamyltransferase 4. AA range:423-472

Specificity：Cleaved-GGT4 HC (T472) Polyclonal Antibody detects endogenous levels of fragment of activated GGT4 HC protein resulting from cleavage adjacent to T472.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GGT7;GGTL3;GGTL5;Gamma-glutamyltransferase 7;GGT 7;Gamma-glutamyltransferase-like 3;Gamma-glutamyltransferase-like 5;Gamma-glutamyltranspeptidase 7;Glutathione hydrolase 7

Observed Band(KD)：50kD

Background： This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008],

Function：catalytic activity:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.,function:Cleaves glutathione conjugates.,pathway:Sulfur metabolism; glutathione metabolism.,similarity:Belongs to the gamma-glutamyltransferase family.,subunit:Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A.,tissue specificity:Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.,

Subcellular Location：Membrane ; Single-pass type II membrane protein .

Expression：Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.