Target：GPC1
Fields：Proteoglycans in cancer;Fluid shear stress and atherosclerosis
Gene Name：GPC1
Protein Name：Glypican-1 [Cleaved into: Secreted glypican-1]
Human Gene Id：2817
Human Swiss Prot No：P35052
Mouse Swiss Prot No：Q9QZF2
Rat Swiss Prot No：P35053
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：GPC1 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：61kD
Background： Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008],
Function：function:Cell surface proteoglycan that bears heparan sulfate.,PTM:This cell-associated glypican is further processed to give rise to a medium-released species.,similarity:Belongs to the glypican family.,
Subcellular Location：Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains.; [Secreted glypican-1]: Secreted, extracellular space.
Expression： Brain,Colon,Lung fibroblast,Salivary gland,
