Target：GP183

Gene Name：GPR183 EBI2

Protein Name：G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2)

Human Gene Id：1880

Human Swiss Prot No：P32249

Mouse Swiss Prot No：Q3U6B2

Rat Swiss Prot No：D4A7K7

Immunogen：Synthesized peptide derived from human protein . at AA range: 110-190

Specificity：GP183 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：39kD

Background： This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008],

Function：caution:It is uncertain whether Met-1 or Met-5 is the initiator.,function:Orphan receptor. Probable mediator of EBV effects on B lymphocytes or of normal lymphocyte functions. Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha.,induction:By EBV.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed:16540462, PubMed:8383238). Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain (PubMed:16540462, PubMed:8383238). Expressed in astrocytes (PubMed:25297897).