Target：GP161

Fields：Hedgehog signaling pathway

Gene Name：GPR161

Protein Name：G-protein coupled receptor 161 (G-protein coupled receptor RE2)

Human Gene Id：23432

Human Swiss Prot No：Q8N6U8

Mouse Swiss Prot No：B2RPY5

Immunogen：Synthesized peptide derived from human protein . at AA range: 180-260

Specificity：GP161 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：58kD

Background： Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008],

Function：function:Orphan receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell projection, cilium membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). .

Expression： Brain,Fetal brain,Teratocarcinoma,Tongue,