Target：Cathepsin Z

Fields：Lysosome;Apoptosis

Gene Name：CTSZ

Protein Name：Cathepsin Z

Human Gene Id：1522

Human Swiss Prot No：Q9UBR2

Mouse Swiss Prot No：Q9WUU7

Immunogen：The antiserum was produced against synthesized peptide derived from human CATZ. AA range:43-92

Specificity：Cleaved-Cathepsin Z (L62) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin Z protein resulting from cleavage adjacent to L62.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CTSZ;Cathepsin Z;Cathepsin P;Cathepsin X

Observed Band(KD)：27kD

Background： The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008],

Function：catalytic activity:Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.,function:Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.,similarity:Belongs to the peptidase C1 family.,tissue specificity:Widely expressed.,

Subcellular Location：Lysosome.

Expression：Widely expressed.