Target：Claudin-2

Fields：Cell adhesion molecules;Tight junction;Leukocyte transendothelial migration;Pathogenic Escherichia coli infection;Hepatitis C

Gene Name：CLDN2

Protein Name：Claudin-2

Human Gene Id：9075

Human Swiss Prot No：P57739

Mouse Gene Id：12738

Mouse Swiss Prot No：O88552

Immunogen：The antiserum was produced against synthesized peptide derived from human Claudin 2. AA range:181-230

Specificity：Claudin-2 Polyclonal Antibody detects endogenous levels of Claudin-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CLDN2;PSEC0059;SP82;Claudin-2;SP82

Observed Band(KD)：25kD

Background： This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],

Function：function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,

Subcellular Location：Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .

Expression： Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,