Target：Cks1

Fields：Pathways in cancer;Small cell lung cancer

Gene Name：CKS1B

Protein Name：Cyclin-dependent kinases regulatory subunit 1

Human Gene Id：1163

Human Swiss Prot No：P61024

Mouse Gene Id：54124

Mouse Swiss Prot No：P61025

Immunogen：The antiserum was produced against synthesized peptide derived from human CKS1. AA range:10-59

Specificity：Cks1 Polyclonal Antibody detects endogenous levels of Cks1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CKS1B;CKS1;PNAS-143;PNAS-16;Cyclin-dependent kinases regulatory subunit 1;CKS-1

Observed Band(KD)：9kD

Background： CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008],

Function：function:Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.,similarity:Belongs to the CKS family.,subunit:Forms a homohexamer that can probably bind six kinase subunits.,

Subcellular Location：cyclin-dependent protein kinase holoenzyme complex,nucleoplasm,SCF ubiquitin ligase complex,

Expression： Brain,Muscle,Promyelocytic leukemia,Prostate,Tongue,