Target：CKR-6

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;Chemokine signaling pathway

Gene Name：CCR6

Protein Name：C-C chemokine receptor type 6

Human Gene Id：1235

Human Swiss Prot No：P51684

Mouse Gene Id：12458

Mouse Swiss Prot No：O54689

Immunogen：The antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR6. AA range:1-50

Specificity：CKR-6 Polyclonal Antibody detects endogenous levels of CKR-6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CCR6;CKRL3;CMKBR6;GPR29;STRL22;C-C chemokine receptor type 6;C-C CKR-6;CC-CKR-6;CCR-6;Chemokine receptor-like 3;CKR-L3;DRY6;G-protein coupled receptor 29;GPR-CY4;GPRCY4;LARC receptor;CD196

Observed Band(KD)：42kD

Background： This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008],

Function：caution:It is uncertain whether Met-1 or Met-6 is the initiator.,domain:Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.,function:Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.,function:Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis.,induction:By interleukin-2.,online information:CC chemokine receptors entry,similarity:Belongs to the cyclin family. Cyclin L subfamily.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CDC2L1 or CDC2L2, SFRS2, SFRS7 and POLR2A, the h

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Cell surface .

Expression：Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.