Target：CIC

Fields：Spinocerebellar ataxia

Gene Name：CIC KIAA0306

Protein Name：Protein capicua homolog

Human Gene Id：23152

Human Swiss Prot No：Q96RK0

Mouse Swiss Prot No：Q924A2

Immunogen：Synthesized peptide derived from human protein . at AA range: 550-630

Specificity：CIC Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：176kD

Background： The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes

Function：function:Transcriptional repressor which may play a role in development of the central nervous system (CNS).,miscellaneous:Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Interact with ATXN1 and ATXN1L.,tissue specificity:Expressed in fetal brain.,

Subcellular Location：Nucleus .

Expression：Expressed in fetal brain.