Target：CHSTE
Fields：Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Gene Name：CHST14 D4ST1 UNQ1925/PRO4400
Protein Name：Carbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1)
Human Gene Id：113189
Human Swiss Prot No：Q8NCH0
Mouse Swiss Prot No：Q80V53
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：CHSTE Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：41kD
Background： This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010],
Function：function:Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA.,similarity:Belongs to the sulfotransferase 2 family.,tissue specificity:Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid.,
Subcellular Location：Golgi apparatus membrane ; Single-pass type II membrane protein .
Expression：Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid.
