Target：CHST1

Fields：Glycosaminoglycan biosynthesis - keratan sulfate

Gene Name：CHST1

Protein Name：Carbohydrate sulfotransferase 1

Human Gene Id：8534

Human Swiss Prot No：O43916

Mouse Gene Id：76969

Mouse Swiss Prot No：Q9EQC0

Rat Gene Id：295934

Rat Swiss Prot No：Q5RJQ0

Immunogen：Synthesized peptide derived from the Internal region of human CHST1.

Specificity：CHST1 Polyclonal Antibody detects endogenous levels of CHST1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CHST1;Carbohydrate sulfotransferase 1;Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1;GST-1;Keratan sulfate Gal-6 sulfotransferase;KS6ST;KSGal6ST;KSST

Observed Band(KD)：49kD

Background： This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011],

Function：catalytic activity:3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.,caution:Was originally (PubMed:9639683) thought to be the ortholog of chicken CHST3 and therefore named C6ST. However, it has no strong chondroitin 6-sulfotransferase activity.,function:Catalyzes the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role i

Subcellular Location：Golgi apparatus membrane ; Single-pass type II membrane protein .

Expression：Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes.