Target：CHD1L

Gene Name：CHD1L

Protein Name：Chromodomain-helicase-DNA-binding protein 1-like

Human Gene Id：9557

Human Swiss Prot No：Q86WJ1

Mouse Gene Id：68058

Mouse Swiss Prot No：Q9CXF7

Immunogen：The antiserum was produced against synthesized peptide derived from human CHD1L. AA range:545-594

Specificity：CHD1L Polyclonal Antibody detects endogenous levels of CHD1L protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CHD1L;ALC1;Chromodomain-helicase-DNA-binding protein 1-like;Amplified in liver cancer protein 1

Observed Band(KD)：101kD

Background：chromodomain helicase DNA binding protein 1 like(CHD1L) Homo sapiens This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012],

Function：function:Putative DNA helicase, which may play a role in chromatin-remodeling. In vitro, promotes cell proliferation and inhibits apoptois.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 Macro domain.,tissue specificity:Frequently overexpresssed in hepatomacellular carcinomas.,

Subcellular Location：Nucleus . Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1. .

Expression：Frequently overexpressed in hepatomacellular carcinomas.