Target：CGGBP1

Gene Name：CGGBP1

Protein Name：CGG triplet repeat-binding protein 1

Human Gene Id：8545

Human Swiss Prot No：Q9UFW8

Mouse Gene Id：106143

Mouse Swiss Prot No：Q8BHG9

Immunogen：The antiserum was produced against synthesized peptide derived from human CGGBP1. AA range:41-90

Specificity：CGGBP1 Polyclonal Antibody detects endogenous levels of CGGBP1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CGGBP1;CGGBP;CGG triplet repeat-binding protein 1;CGG-binding protein 1;20 kDa CGG-binding protein;p20-CGGBP DNA-binding protein

Molecular Weight(Da)：19kD

Background： CGGBP1 influences expression of the FMR1 gene (MIM 309550), which is associated with the fragile X mental retardation syndrome (MIM 300624), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.[supplied by OMIM, Mar 2008],

Function：developmental stage:Expressed in fetal brain and kidney. Lower expression in fetal liver and lung.,function:Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter.,miscellaneous:Binding is severely inhibited by complete or partial cytosine-specific DNA methylation of the binding motif.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,tissue specificity:Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain.,

Subcellular Location：Nucleus .

Expression：Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain.