Target：Cerebral 1
Gene Name：RRP8
Protein Name：Ribosomal RNA-processing protein 8
Human Gene Id：23378
Human Swiss Prot No：O43159
Mouse Swiss Prot No：Q9DB85
Immunogen：The antiserum was produced against synthesized peptide derived from human HUCE1. AA range:271-320
Specificity：Cerebral 1 Polyclonal Antibody detects endogenous levels of Cerebral 1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：RRP8;KIAA0409;NML;hucep-1;Ribosomal RNA-processing protein 8;Cerebral protein 1;Nucleomethylin
Observed Band(KD)：51kD
Background：RRP8 (Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast) is a Protein Coding gene. Diseases associated with RRP8 include bowen-conradi syndrome and lymphatic system cancer. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and methylated histone binding. ssential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Function：rRNA processing, RNA processing, rRNA metabolic process, ribonucleoprotein complex biogenesis, ncRNA processing,ncRNA metabolic process, ribosome biogenesis,
Subcellular Location：Nucleus, nucleolus . Localizes at rDNA locus.
