Target:Cerebellin 3
Gene Name:CBLN3
Protein Name:Cerebellin-3
Human Gene Id:643866
Human Swiss Prot No:Q6UW01
Mouse Gene Id:56410
Mouse Swiss Prot No:Q9JHG0
Immunogen:The antiserum was produced against synthesized peptide derived from human CBLN3. AA range:131-180
Specificity:Cerebellin 3 Polyclonal Antibody detects endogenous levels of Cerebellin 3 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:CBLN3;Cerebellin-3
Observed Band(KD):27kD
Background: Members of the precerebellin family, such as CBLN3, contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal C1q signature domain (see MIM 120550) that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix (Pang et al., 2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009],
Function:function:May be involved in synaptic functions in the CNS.,similarity:Contains 1 C1q domain.,subcellular location:Secretion depends probably on a association with CBLN1 or perhaps CBLN4 but not on CBLN2.,subunit:Heterohexamer; disulfide-linked heterotrimers. Does not homooligomerize, but probably forms a complex with at least CBLN1. May interact with CBLN2 and CBLN4.,
Subcellular Location:Endoplasmic reticulum . Golgi apparatus, cis-Golgi network . Secreted . Cell junction, synapse . In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on an association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity). .