Target：LSHB

Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;GnRH signaling pathway;Ovarian steroidogenesis;Prolactin signaling pathway;GnRH secretion

Gene Name：LHB

Protein Name：Lutropin subunit beta (Lutropin beta chain) (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta)

Human Gene Id：3972

Human Swiss Prot No：P01229

Mouse Swiss Prot No：O09108

Rat Swiss Prot No：P01230

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：LSHB Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：15kD

Background： This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008],

Function：disease:Defects in LHB are a cause of hypogonadism [MIM:152780]. Hypogonadism is characterized by infertility and pseudohermaphroditism.,function:Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.,online information:Luteinizing hormone entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the glycoprotein hormones subunit beta family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,tissue specificity:Pituitary gland.,

Subcellular Location：Secreted.

Expression：Pituitary gland.