Target：LSM1

Fields：RNA degradation

Gene Name：LSM1 CASM

Protein Name：U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)

Human Gene Id：27257

Human Swiss Prot No：O15116

Mouse Swiss Prot No：Q8VC85

Immunogen：Synthesized peptide derived from human protein . at AA range: 50-130

Specificity：LSM1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：14kD

Background：LSM1 homolog, mRNA degradation associated(LSM1) Homo sapiens This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011],

Function：function:Binds specifically to the 3'-terminal U-tract of U6 snRNA.,similarity:Belongs to the snRNP Sm proteins family.,subunit:LSm subunits form a heteromer with a donut shape.,tissue specificity:Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.,

Subcellular Location：Cytoplasm . Cytoplasm, P-body .

Expression： Eye,Lymph node,