Target：LSP1

Fields：C-type lectin receptor signaling pathway;Tuberculosis

Gene Name：LSP1

Protein Name：Lymphocyte-specific protein 1

Human Gene Id：4046

Human Swiss Prot No：P33241

Mouse Swiss Prot No：P19973

Immunogen：The antiserum was produced against synthesized peptide derived from human LSP1. AA range:104-153

Specificity：LSP1 Polyclonal Antibody detects endogenous levels of LSP1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LSP1;WP34;Lymphocyte-specific protein 1;47 kDa actin-binding protein;52 kDa phosphoprotein;pp52;Lymphocyte-specific antigen WP34

Observed Band(KD)：37kD

Background： This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Function：function:May play a role in mediating neutrophil activation and chemotaxis.,PTM:Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis.,subunit:Binds actin.,tissue specificity:Activated T-lymphocytes.,

Subcellular Location：Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Expression：Activated T-lymphocytes.