Target：CEAM7

Gene Name：CEACAM7 CGM2

Protein Name：Carcinoembryonic antigen-related cell adhesion molecule 7 (Carcinoembryonic antigen CGM2)

Human Gene Id：1087

Human Swiss Prot No：Q14002

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CEAM7 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：29kD

Background： This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],

Function：similarity:Belongs to the immunoglobulin superfamily. CEA family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:Strongly down-regulated in colonic adenocarcinomas.,

Subcellular Location：Cell membrane ; Lipid-anchor, GPI-anchor . Apical cell membrane . Localized to the apical glycocalyx surface. .

Expression：Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). Strongly down-regulated in colonic adenocarcinomas.